Illustration

USMLE Step 1

Released Items Explained

Every fall, the NBME ( National Board of Medical Examiners) releases 150 sample questions for candidates to see what USMLE Step 1 questions look like. They publish the items on CD-ROM; they also can be downloaded from the USMLE web site. It is important for you to review these items, as they are similar in both format and content to those on the real exam.

What the NBME doesn't provide are the explanations. That's where we offer you our USMLE preparation courses! We have written comprehensive explanations to all 150 items, including discussions of why the right answers are right and why all the distracters are wrong. Please note that the questions themselves are copyrighted by the NBME and can not be reproduced. If you don't already have the USMLE's CD-ROM, visit www.usmle.org.

Test Yourself!

Our Kaplan courses offers the most USMLE-style practice questions. The courses questions are in a vignette format and reflect the "higher order" style featured on the most recent exam administrations. Every question includes comprehensive explanations that include a detailed review of the correct answer and provide explanations for why each distracter is wrong. Preview FREE sample questions and explanations taken from our review programs for the USMLE Step 1.

Step 1 Sample Items

1. A 32-year-old construction worker arrives in the emergency department after an accident on the job. The tendon of the biceps brachii at the elbow has been severed by a laceration that extends 2 cm medially from the tendon. Which of the following structures is likely to have been injured by medial extension of the laceration?

(A)Brachial artery
(B)Musculocutaneous nerve
(C)Profunda brachii artery
(D)Radial nerve
(E)Ulnar nerve

2. A 52-year-old man presents to his physician after a community health screening test reveals a fasting glucose of 170 mg/dL. Physical examination is remarkable for bronze skin pigmentation, hepatomegaly, splenomegaly, and limitation of motion in the second and third metacarpophalangeal joints of both hands. A liver biopsy obtained from the patient is shown above. The man has no known history of hemolytic anemia and takes daily multivitamins without minerals. Which of the following pigments is most likely present in the man's liver?

(A)Bilirubin
(B)Carotene
(C)Ferritin
(D)Lipofuscin
(E)Melanin
3. A 57-year-old woman with a history of hypertension and arthritis is referred to a rheumatologist for evaluation. A complete blood count (CBC) is normal, and a mini-chem panel shows no electrolyte abnormalities. Her erythrocyte sedimentation rate (ESR) is elevated, and an antinuclear antibody test (ANA) is positive. Further antibody studies are performed, and the results are shown below.

Anti-histoneshigh titer
Anti-double stranded DNAnot detected
Anti-single stranded DNAnot detected
Anti-SSAnot detected
Anti-SSBnot detected
Anti-SCI-70not detected
Anti-Smithnot detected
Anti-centromerenot detected
Anti-RNPnot detected

Which of the following diseases is suggested by these results?

(A)CREST syndrome
(B)Diffuse form of scleroderma
(C)Drug-induced lupus
(D)Sjögren syndrome
(E)Systemic lupus erythematosus

4. During a fight, a 32-year-old man is hit on the back of the neck with a chair. A CT scan reveals a bony fragment that penetrated the lateral portion of the dorsal columns. Which of the following functions would most likely be affected by this lesion?

(A)Fine motor control of the ipsilateral fingers
(B)Motor control of the contralateral foot
(C)Sweating of the ipsilateral face
(D)Proprioception from the ipsilateral leg
(E)Vibratory sense from the ipsilateral arm

5. A 15-year-old high school student and several of her friends ate lunch at a local Chinese restaurant. They all were served the daily special, which consisted of sweet and sour pork with vegetables and fried rice. All the girls developed nausea, vomiting, abdominal pain, and diarrhea within 6 hours of eating lunch. Which of the following organisms is the most likely cause of these symptoms?

(A)Bacillus cereus
(B)Clostridium botulinum
(C)Clostridium perfringens
(D)EHEC (enterohemorrhagic Escherichia coli)
(E)Staphylococcus aureus
(F)Vibrio cholerae